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Orchestrated objective reduction (Orch-OR) is a hypothesis that consciousness in the brain originates from processes inside neurons, rather than from connections between neurons as in the conventional view. The mechanism is held to be a quantum physics process called objective reduction which is orchestrated by molecular structures called microtubules. The hypothesis, which was put forward in the early 1990s by theoretical physicist Roger Penrose and anaesthesiologist and psychologist Stuart Hameroff, has so far been rejected by the majority of cognitive scientists.

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